Chronic post-surgical pain (CPSP) is highly prevalent in children with an incidence of 15-43%. It affects the child’s psychological and physical health, and family well-being and has a large socioeconomic impact on the community. Individual and environmental factors are associated with CPSP,  including preoperative pain, poorly controlled acute postoperative pain, parental pain catastrophizing, psychosocial factors, and social disadvantages.  Understanding the interplay between individual, family, and environmental factors is key to providing patient-centered interventions. We have assembled an international, multidisciplinary panel including an individual with lived experience of CPSP, to provide a comprehensive understanding of the impact of CPSP. We will start with a personal account of lived experience with CPSP by our patient partner followed by an overview of prevalence and risk factors. We will elaborate on various mechanisms based on psychophysical and neuroimaging studies. We will explore genomic, immunologic, and gene-environmental interactions underlying nociceptive priming and pain sensitization. We will also discuss population health and disparities in CPSP and the effect of social determinants of health in pain management.   Finally, panelists will discuss personalization/models of care, offering potential solutions. Format: Introductions and “big-picture” presentations (30 minutes) followed by an interactive moderated discussion between panelists (25 minutes), interspersed with audience polls, and finally audience Q and A session (20 minutes).