During the “big picture” portion of the panel, Dr. Sieberg will provide an overview of her research from her various grant-funded studies, including from her current NIH R35 Maximizing Investigator’s Research Award, on pediatric chronic postsurgical pain (CPSP). She will present neuroimaging data integrating Quantitative Sensory Testing, including paradigms of descending pain inhibition (e.g., Offset Analgesia) with psychosocial functioning and stress biomarkers that highlight risk factors for pain chronification, the maintenance of pain, and behavioral treatment response, via a mechanistic clinical trial of an Acceptance and Commitment Therapy intervention for CPSP. During the Q&A panel, Dr. Sieberg can discuss these studies in more detail and also highlight gaps, challenges, and proposed solutions in pediatric CPSP. Additionally, during the Q&A, she can discuss various data and projects from her group highlighting these concepts including differential gene expression of the HLA-complex in pediatric spinal fusion patients who transition to CPSP, pre, intra, & post-operative resting state & evoked fNIRS data, and her published theoretical model of pediatric CPSP, which encompasses a process that involves ongoing and continuous evaluation and treatment of pre-mitigating factors to premorbid status, injury and immediate postinjury treatments, objective assessment of pain chronification, and treatment rehabilitative processes.