This symposium will highlight how cross-disciplinary science can propel novel directions in pediatric pain research and treatment. Specifically, the speakers (Kashikar-Zuck, Myers) will discuss how synergistic collaboration from the fields of behavioral medicine and sports medicine evolved into the creation of the Fibromyalgia Integrative Training (FIT Teens) program for the treatment of juvenile fibromyalgia (JFM) in adolescents. The ongoing multi-center FIT Teens trial infrastructure has facilitated collaborative translational research including sophisticated biomechanical measurement of movement patterns in adolescents and fMRI studies of structural and functional alterations in pain processing in JFM (Lopez-Sola). This cross-disciplinary seminar will highlight how a multi-institutional collaboration between three research disciplines are, for the first time, beginning to 1) elucidate sensory integration and pain processing impairments underlying JFM symptoms, 2) demonstrate the role of altered movement patterns that contribute to physical impairment and fear of movement, and 3) integrate findings to inform more mechanistically-driven, non-pharmacologic treatments for complex chronic pain conditions in children.