Pain is influenced by sex and gender, and this influence differs depending on developmental stage. Pain is more common in adolescent girls, and is associated with increased emotional distress. Autism is also influenced by sex and gender, with different behavioural profiles in girls and boys, and diagnostic practices that are more sensitive to the male phenotype. Very little research has examined sex- or gender-related factors in the relationship between pain and autism. Dr. Boerner will introduce new qualitative data describing the unique experiences of youth who identify as both gender- and neuro-diverse, and who live with chronic pain. She will also describe recent patient engagement initiatives to increase the accessibility of in-home pain research methods for autistic youth, and how these methods are being used to provide a microlongitudinal multimodal examination of the intersection of pain, sex, and gender in autistic youth. This will be discussed in the context of identifying adaptations for pain therapies that are accessible and affirming in the context of neurodiversity and gender diversity.