The three conferences that will be presented in this symposium will cover different clinical contexts where virtual reality (VR) was used and tested in both hospitalized and ambulatory clinical contexts. This symposium will focus on the use of VR for pain and anxiety management of children hospitalized for treatment of cancer as well as in children visiting the orthopedic clinics for bone pins’ and/or sutures removal following a fracture. Also, we will present a pilot study on the experience related to the implementation of virtual reality within some of the clinical units of an orthopedic pediatric hospital. Participants will have an opportunity, at the end of all presentations, to discuss the results presented as well as provide suggestions or share their own experience using VR with children as a distraction for management of procedural pain and anxiety or initiatives for implementation of VR within their own institution.