The International Association for the Study of Pain’s 2022 Global Year for Translating Pain Knowledge into Practice highlighted the importance of partnering with patients across professional undertakings to ensure relevance and impact in both research and clinical care. Partnering with patients and caregivers in planning, conducting, and disseminating research can improve research quality and delivery of pediatric pain services and policies; however, many researchers, clinicians, and other health care stakeholders are at best uncertain about, if not completely unaware of, how to partner with patients. Drawing on the experiences of international panelists, including a patient, we will outline and discuss a variety of creative and meaningful ways patients and caregivers can and have been engaged as part of research and clinical implementation teams. Concrete examples will be shared across a spectrum of patient involvement and engagement (inform, consult, involve, collaborate, and empower) to guide pediatric pain research and development of clinical services.