Despite the high prevalence, cost, and impact of chronic pain in children and adolescents, the evidence base for chronic pain interventions is limited. Appropriate outcome measures and high-quality intervention trials are critical to advancing care. The prior PedIMMPACT recommendations published in 2008 have been used to guide outcomes measurement in clinical registries and trials but overall had modest uptake over the past 14 years, potentially due to the limitations in the methodology used. This symposium provides timely updates on a new core outcome set for pediatric chronic pain interventions that involved collecting providers’, patients’, and parents’ perspectives about treatment of pediatric chronic pain to understand clinically meaningful outcomes that should be routinely measured. Youth with neurodevelopmental disabilities have been neglected from previous core outcome sets for pediatric chronic pain. A new systematic review identifies pain and functioning outcome measures and future recommendations to address this research gap. The newly developed Patient-Reported Outcome Measurement Information System (PROMIS®) pediatric measures provide opportunity for inclusion in core outcome sets but need systematic evaluation. Recommendations for their use in children and adolescents with chronic pain are made following a systematic review of their measurement properties.