Dr. Sieberg will present research from her various grant funded studies that have utilized Quantitative Sensory Testing (QST), including paradigms of descending pain inhibition (e.g., Conditioned Pain Modulation; Offset Analgesia) to identify young people who demonstrate amplified central nervous system processing of pain-related information and who are at elevated risk for adverse pain-related outcomes and reduced benefits of pain-reducing treatments, with a focus on chronic postsurgical pain (CPSP) and endometriosis-associated pain (EAP). Dr. Sieberg is the PI on an R35 Maximizing Investigator’s Research Award from the NIH to focus on brain state and treatment of CPSP across the lifespan and she is the MPI of a grant from the US Department of Defense utilizing neuroimaging to define the role for descending pain inhibition and reward-aversion processes towards the development of EAP in young people. Specifically, she will highlight how her research has integrated QST assessment into neuroimaging protocols, both functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) in order to study risk factors for pain chronification, the maintenance of pain, and behavioral treatment response, via a mechanistic clinical trial of an Acceptance and Commitment Therapy intervention for CPSP and present findings from these ongoing studies.