This session will provide an overview of school-based interventions for chronic pain and somatic symptoms: What has been successful, what do we know, and what are the barriers and facilitators for pain-specific health promotion interventions in schools? What is important for success and sustainable implementation? Kory Zimney will give a general introduction reviewing the significance of chronic pain in childhood. He will then map out the course of a series of studies on the development and implementation of pain neuroscience education in middle schools in the US, sharing lessons learned. Afterward, other real-world examples will be presented: Catherine Stewart presents her findings with school nurse-delivered interventions for youth anxiety and related somatic symptoms. Henrike Brunsmann introduces a web-based educational headache intervention to 5th and 6th-grade students that have been evaluated in a randomized-controlled trial.