This interactive panel presentation will focus on lessons learned in some of the most well-established intensive interdisciplinary pediatric pain treatment (IIPT) programs regarding how to apply the IIPT model of care to patients presenting with “pain-adjacent” conditions and with common comorbidities that present challenges to the traditional treatment approaches. We will also discuss how to adapt the model for patients with a variety of demographic characteristics beyond the historically-typical adolescent female profile. Integrating clinical outcomes data with case examples that will highlight both successes and challenges/areas for improvement, the panelists will discuss how their programs have managed the following presentations: (1)   Pain-adjacent presenting conditions: e.g. Postural orthostatic tachycardia syndrome (POTS); Functional Neurologic Disorders (FND); (2)   Common comorbidities:  e.g. Hypermobility; Neurodivergent conditions (3)   Demographic characteristics: e.g. Gender diverse identities; Young adults; Social determinants of health Presenters will briefly present IIPT outcome data on the patient populations listed above. The majority of the time will focus on a lively, dynamic discussion amongst panelists including frank discussions of treatment efforts that worked and did not work and debates about appropriateness of IIPT for specific patient groups. Through active moderation, the panelists will also engage the audience in this discussion format.