Understanding pain processes over the first years of life is an important area of study, as the implications of these processes ripple across not only childhood but other life stages.  Implicit in this ripple effect is that there is a malleability that can support early intervention for more adaptive pain experiences as one ages. While pain is ubiquitous, how pain is experienced and expressed takes shape uniquely for each individual based on an idiosyncratic synthesis of biological, psychological, and social experiences.  Taking a multidisciplinary perspective, this international panel will take a deeper dive into three distinct developmental phases of early childhood and important influences that shape pain responses. Dr. Ranger, an early career nurse scientist, will present original findings on whether early repeated exposure to pain, sucrose, or a combination of the two, affects inflammatory markers and induces brain microgliosis in neonatal mice.  Professor. Pillai Riddell, a basic behavioural scientist and clinical psychologist, will present novel results regarding regulatory patterns of parent-child attunement during vaccinations over the second year of life.  Finally, Dr. Wallwork, a postdoctoral fellow in physiotherapy, will present new findings regarding how parents and other caregivers can build resilience in pre-schoolers through the power of narratives.