The advancement of the field of pediatric pain has beckoned for new research approaches to address ongoing and novel issues within how children’s pain is understood and managed. Advances in technology and experimental research methodologies present innovative opportunities to generate modern solutions and understandings in pediatric pain, including the promotion of equity and accessibility in research and care. This symposium, led by an international (i.e., Canada, United States), multidisciplinary panel (i.e., psychology, nursing) will present three innovative approaches to understanding and managing children’s acute and chronic pain. The first speaker will present a choice experiment method to understanding partner priorities when implementing evidence for pediatric pain management. The second speaker will detail a novel mixed methods approach to adapting evidence-based digital health interventions to improve engagement and benefit for vulnerable sub-groups of youth with chronic pain, highlighting the integration of methods including meta-analysis, component profile analysis, qualitative interviews, and validated self-report measurements. The third speaker will present a qualitative approach combining theory and stakeholder perspectives to inform implementation interventions in infant pain. Examples from the speakers’ research will demonstrate applications of these methods and how they can be utilized in support of best practices in pediatric care.